CJASN 에 만성신질환 환자에서의 통증조절에 대한 내용이 나와 있어 인용합니다. Anticonvulsants and tricyclic antidepressants are the two classes of drugs for which there is most evidence of efficacy. Systematic reviews have found that anticonvulsants and tricyclic antidepressants are effective in reducing neuropathic pain due to diabetic peripheral neuropathy and postherpetic neuralgia (그래서 요새 amitriptyline 을 많이 사용해보고 있는데, 아직까지 드라마틱한 효과를 보지는 못했다.) Gabapentin is structurally similar to the neurotransmitter γ-aminobutyric acid but, rather than bind to γ-aminobutyric acid receptors, its mechanism of action is thought to be through binding to calcium channels and modulating the influx of calcium. Gabapentin is almost exclusively cleared by the kidneys and substantial dose reduction is required as the GFR declines to avoid toxicity. Adverse effects include somnolence, dizziness, peripheral edema, and gait disturbances. Evidence suggests that carbamazepine may be as effective as gabapentin for treating neuropathic pain in the general population and may have fewer adverse effects. Unlike gabapentin, it requires no dose adjustment in CKD. (잘 몰랐던 carbamazepine 이라는 약. gabapentin 만큼 효과가 있고, CKD 에서 용량 조절이 불필요하단다.) 구분 상품명 제조/수입사 오리지널 제품 테그레톨정 (Tegretol Tab.) 한국노바티스 오리지널 서방형제제 테그레톨씨알정 (Tegretol-CR Tab.) 한국노바티스 제네릭 … 더 읽기